RIDASCREEN® IFX Monitoring

Intended use:

RIDASCREEN® IFX Monitoring is an enzyme linked immunoassay intended for the quantitative determination of infliximab (IFX, Remicade®, anti-TNFα) and its biosimilars Remsima®, Inflectra® and Flixabi® in human serum and plasma.

Key features of RIDASCREEN® IFX Monitoring:

• validated in clinical trials
• highly specific monoclonal antibody MA-IFX6B7, which has also been used in the TAXIT-study (KU Leuven)
• equally well suited for TDM of Remicade®, Inflectra®, and Remsima®
• 2 controls at the decision sites (3 and 7 µg/ml IFX)
• breakable microwell plate
• validated for automated 4-Plate-ELISA-Reader (e.g. DSX).

* KU Leuven (Belgium) was conducting the Taxit study which demonstrated the positive effect of therapeutic drug monitoring (TDM) of Infliximab (IFX) in regards to cost saving and therapy optimization. They are world leaders in drug monitoring..

Individual dose adjustment by measuring drug levels

Due to individual pharmacokinetics, different people show different drug levels in the blood even though they receive identical IFX dosage. However, a certain drug concentration in the patient’s blood must be present to be effective. By therapeutic drug monitoring of infliximab this can be checked and the dosage can be optimally adjusted to the needs of the patient.

For this purpose, the IFX drug concentrations in the blood are tested before the next infusion. In addition to the therapeutic benefits, TDM of infliximab helps reducing the cost of treatment.